An Online Course with Dr James Lyons-Weiler, PhD

INSTRUCTOR: James Lyons-Weiler, PhD

Dr. James Lyons-Weiler is the founder and CEO of the Institute for Pure and Applied Knowledge, also known as IPAK. He is the author on 58 peer-reviewed publications, and has written and published three books, one on Ebola, another on Cures vs. Profits and a third on The Environmental and Genetic Causes of Autism”. He, along with other scientists at IPAK, perform research in the public interest aimed at finding ways to reduce human suffering using funds donated from the public and that he raises at IPAK educational events. His latest research shows that US FDA has never issued a pediatric dose limit for aluminum that considers body weight, and finds that on the CDC schedule, infants are in aluminum toxicity 100% of their days in the first year of life. His research program is currently focused on aluminum toxicity, autoimmunity, and the differences in health outcomes between highly vaccinated and unvaccinated children.


In this course, the etiologies of cancer will be explored from a systems biology perspective. Each lecture will review current knowledge from recent and classical peer-reviewed literature. The course is divided into three parts. In Part 1, the role and interplay of genetic and environmental risk of cancer will be reviewed. Particular attention will be given to the types of genes that confer risks of various cancer types by well-characterized mechanisms.

In the second part, the lectures will focus on the evolution of ideas stemming from Hanahan & Weinberg’s “Hallmarks of Cancer.” Students will read critiques and extensions of Hanahan & Weinberg’s concepts.

In the third part, these concepts will be explored in detail across a diverse range of cancer types

Students will leave the course with a deep appreciation of the general cellular and molecular pathogenesis of cancer as well as a command of recent knowledge of unique features of cancer etiology in a variety of specific tissues of origin.


Part I: Lectures 1-3

1. Course Overview

2. Cancer Genetics

3. Mutagens and Carcinogens

Part II: Lectures 4-13

Evolving Views on the Hallmarks of Cancer

Part III: Specific Cancers

14. Breast Cancer

15. Ovarian Cancer

16 Uterine Cancer

17. Skin Cancer

18. Prostate Cancer

19. Brain Cancers

20. Cancers of the Blood

21. GI Tract

22. Lung Cancer

23. Pediatric Cancers

24. Bonus: The Role of Viruses in Cancer


Unit One – Course Overview & The Genetics of Cancer (96:28)

Unit 2 – Environmental Factors and GxE (37:31)

Unit 3 – The Hallmarks of Cancer (54:12)

Unit 4 – Hallmarks of Cancer: The Next Generation (49:14)

Unit 5 – Hallmarks of Cancer Revisited (51:55)

Unit 6 – Metastasis in Death (52:25)

Unit 7 – Hallmarks of Cancer and Wound Healing (33:03)

Unit 8 – Hallmarks of Cancer of Unknown Primary (37:31)

Unit 9 – Hallmarks of Cancer – The New Testament

Unit 10 – Hallmarks of Cancer – As Ecologically Driven Phenotypes

The Biology of Cancer – Breast Cancer (43:12)

The Biology of Cancer – Lung Cancer (38:35)

The Biology of Cancer – Prostate Cancer (41:45)

Bonus Lecture – Questioning the Current Model (43:04)